Discovery of a Small-Molecule Modulator of the Autophagy Lysosome Pathway That Targets Lamin A/C and LAMP1, Induces Autophagic Flux, and Affects Lysosome Positioning in Neurons

Sruchi Patel; Amanda Snead; Swetha Gowrishankar

doi:10.51894/001c.164011

July 30, 2026Spartan Medical Research JournalOpen Access

Discovery of a Small-Molecule Modulator of the Autophagy Lysosome Pathway That Targets Lamin A/C and LAMP1, Induces Autophagic Flux, and Affects Lysosome Positioning in Neurons

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Key Points

This research aims to identify a small-molecule modulator that impacts the autophagy lysosome pathway in neurons.
Identified a small-molecule modulator targeting lamin A/C and LAMP1.
Assessed effects on autophagic flux and lysosome positioning in neuronal cells.
Induced significant autophagic flux in treated neurons.
Observed alterations in lysosome positioning across different neuron types.

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Implication

Discovery of a modulator influencing lysosomal positioning and autophagic activity in neurons, suggesting therapeutic potential.

Abstract

By Sruchi Patel, Amanda Snead & 1 more. Discovery of a Small-Molecule Modulator of the Autophagy Lysosome Pathway That Targets Lamin A/C and LAMP1, Induces Autophagic Flux, and Affects Lysosome Positioning in Neurons

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Patel et al. (2026) studied this question.

synapsesocial.com/papers/6a6d984be258b358b3c6b714 https://doi.org/10.51894/001c.164011

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Discovery of a Small-Molecule Modulator of the Autophagy Lysosome Pathway That Targets Lamin A/C and LAMP1, Induces Autophagic Flux, and Affects Lysosome Positioning in Neurons

Key Points

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Implication

Abstract

Discussion

Cite This Study

Discovery of a Small-Molecule Modulator of the Autophagy Lysosome Pathway That Targets Lamin A/C and LAMP1, Induces Autophagic Flux, and Affects Lysosome Positioning in Neurons

Key Points

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Implication

Abstract

Discussion

Cite This Study

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