PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
August 1, 2026The Journal of Clinical PharmacologyOpen Access

Volumetric Absorptive Microsampling During Spaceflight for Analysis of Acetaminophen Pharmacokinetics in Whole Blood

View Full Paper
Ask AI
Bookmark
Share

Authors

DMDavid MampreRGRobert GuttendorfJZJennifer Zimmer

Discussion

Loading...

Member takes

Overview

Randomized trial analyzes acetaminophen pharmacokinetics in microgravity, suggesting significant physiological changes.

Key Points

  • This research aims to analyze how spaceflight affects acetaminophen pharmacokinetics in whole blood.
  • Four crewmembers ingested 500 mg of acetaminophen pre-flight, in-flight, and post-flight.
  • Blood samples were collected using volumetric absorptive microsampling and analyzed with liquid chromatography-tandem mass spectrometry.
  • Comparisons were made between pre-flight and in-flight pharmacokinetic parameters.
  • C max increased from 9110 ng/mL pre-flight to 43,300 ng/mL in-flight (P < .001).
  • AUC increased from 26,100 h ng/mL pre-flight to 109,000 h ng/mL in-flight.
  • t 1/2 decreased from 3.27 h pre-flight to 2.07 h in-flight, indicating altered drug metabolism.

Cite This Study

Mampre et al. (2026) studied this question.

synapsesocial.com/papers/6a6d9868e258b358b3c6bb24https://doi.org/10.1002/jcph.70240
View Full Paper
Ask AI
Bookmark
Share