Key result
Planned meta-analysis evaluates how device-measured daily steps and cadence associate with cardiovascular disease-free life expectancy.
Why the study?
Is device-measured daily step volume and cadence associated with cardiovascular disease-free life expectancy?
Meta-Analysis
Yes
Is device-measured daily step volume and cadence associated with cardiovascular disease-free life expectancy?
This protocol outlines a harmonized meta-analysis to evaluate the association of daily steps and cadence with cardiovascular disease-free life expectancy.
This record contains version 1.0 of the protocol for a harmonized two-stage individual participant data meta-analysis of prospective cohort studies. The study will examine the association of device-measured daily step volume and cadence with cardiovascular disease-free life expectancy. Participating cohorts will apply a standardized harmonization and statistical analysis protocol locally, and cohort-specific estimates will subsequently be pooled using meta-analysis. The primary outcome is time to the first fatal or non-fatal cardiovascular event, with cancer incidence considered as a secondary outcome or for a secondary manuscript.
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Vidal‐Almela et al. (2026) conducted a meta-analysis in Cardiovascular disease. Device-measured daily step volume and cadence was evaluated on Time to the first fatal or non-fatal cardiovascular event. This protocol outlines a planned meta-analysis of prospective cohorts to evaluate the association of device-measured daily step volume and cadence with cardiovascular disease-free life expectancy.
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