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August 1, 2026Clinical Endocrinology

Maternal–Neonatal Metabolic Continuity and Early Postnatal HPG Axis Activity in Healthy Term Neonates

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Authors

MKMerve KocaGaziantep UniversityMKMurat KaraoğlanGaziantep UniversityNTNeslihan Bayramoğlu TepeGaziantep University

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Implication

Randomized trial evaluates maternal metabolic influences on early neonatal hormone activity, suggesting limited associations.

Key Points

  • To evaluate the relationship between maternal metabolic markers and early neonatal reproductive hormone activity.
  • Prospective evaluation of 40 healthy term neonates and their mothers.
  • Maternal and neonatal blood samples analyzed for adipokines and reproductive hormones.
  • Used correlation and regression analyses, with FDR correction for multiple testing.
  • Maternal leptin positively associated with neonatal leptin (r = 0.52, p = 0.001).
  • No significant association between maternal leptin and neonatal LH levels (β = 0.00009, p = 0.347), with sex remaining a strong predictor (β = 1.21, p = 0.011).
  • Neonatal leptin associated with triceps skinfold thickness (β = 1503.14, p = 0.034).

Cite This Study

Koca et al. (2026) studied this question.

synapsesocial.com/papers/6a6d989ee258b358b3c6c422https://doi.org/10.1111/cen.70193
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