Randomized trial reveals dietary plant polysaccharides affect brain aging outcomes, suggesting new treatment paths.
Plant PS are promising dietary modulators of brain aging but not established neurotherapeutics. Translation requires standardized fractions, control of co-extracted phenolics and proteins, dose-response studies and biomarker-rich clinical trials incorporating stool and plasma SCFAs, inflammatory markers, neurofilament light, phosphorylated tau, cognitive outcomes and neuroimaging measures.
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Bagul et al. (2026) studied this question.
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