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Bone tumors with high mortality and disability have become a major clinical challenge. Herewith, it is necessary to design materials for bone tumor therapy and bone repair. In this work, Fe-doped polypyrrole (Fe-Ppy) and CaO 2 are constructed on sulfonated polyetheretherketone (SP) to form a multistage-responsive coating. The coating achieves long-lasting antitumor through chemodynamic therapy (CDT), photothermal therapy (PTT), and combined immunotherapy. Fe-Ppy acts as an electron pump to replenish Fe 2+ through oxidizing –NH– to –N + –, which lasts the Fenton reaction and persistently produces reactive oxygen species (ROS) in the tumor microenvironment (TME). CaO 2 selectively provides exogenous H 2 O 2 in response to TME to boost the electron cycle. Stronger near-infrared light absorption due to Fe doping and more photon traps caused by porous structure-induced scattering and refraction diminishment improve the photothermal conversion of modified SP. Furthermore, long-lasting ROS and effective photothermal conversion enhance M1 activation to secrete TNF-α and IFN to kill tumor cells. After tumor therapy, Fe-Ppy@CaO 2 -modified SP could adaptively switch the macrophage to M2 and promote osteogenesis with the abolishment of TME and NIR stimulation. In summary, Fe-Ppy@CaO 2 -modified SP with long-lasting ROS, enhanced photothermal conversion, and immunomodulation is a potential candidate for bone tumor therapy and tissue repair.
Liu et al. (Tue,) studied this question.