Key result
Type 1 diabetes in youth is linked to poorer cardiac autonomic function and ~30% neuropathy prevalence.
Why the study?
Does type 1 diabetes impair cardiac autonomic function in children and youth compared to healthy siblings?
Case-Control (n=60)
Does type 1 diabetes impair cardiac autonomic function in children and youth compared to healthy siblings?
p-value: p=0.027
Children and youth with type 1 diabetes exhibit significantly reduced cardiac autonomic function compared to healthy siblings, highlighting the potential need for early screening.
May support early autonomic screening in pediatric type 1 diabetes; extends adult data but leaves open prospective validation.
This study compared the cardiac autonomic function in 30 children and youth with type 1 diabetes (T1D) with 30 age- and sex-matched healthy siblings using Cardiovascular Autonomic Reflex Tests (CARTs). The T1D group showed consistently poorer performance across all parameters, indicating reduced autonomic function. The 30:15 ratio was significantly lower in the T1D group ( P = 0.027), suggesting impaired heart rate response to postural change. Cardiac autonomic neuropathy (CAN) was identified in 30% of cases. These findings underscore the importance of early CAN screening in young individuals with T1D.
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Bhade et al. (2026) conducted a case-control in Type 1 diabetes (n=60). Type 1 diabetes vs. Age- and sex-matched healthy siblings was evaluated on 30:15 ratio (heart rate response to postural change) (p=0.027). Type 1 diabetes in children and youth was associated with significantly poorer cardiac autonomic function, including a lower 30:15 ratio (P=0.027) and a 30% prevalence of cardiac autonomic neuropathy.
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