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A green and efficient protocol has been developed for the Pd(OAc)₂-catalyzed ligand-free Suzuki--Miyaura reaction of N-methyliminodiacetic acid (MIDA) boronates in water. In the presence of Pd(OAc)₂ as a catalyst and (i-Pr)₂NH as a base, the cross-coupling reactions of aryl bromides with aryl MIDA boronates proceeded smoothly in water without any surfactant, and various functional groups were tolerated under the optimized conditions.
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Liu et al. (2015) studied this question.