NO beating. N ω,N ω-Dimethyl-L-arginine dimethylaminohydrolase (DDAH, see Figure) is a regulator of NO production in mammalian organisms. Among the many approaches to inhibit NO production for the treatment of severe diseases like migraine, ischemia, septic shock, or cancer, inhibition of DDAH is a novel and promising one. Research progress in its (patho)physiology and biochemistry is described and discussed in this article.
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Markus Knipp (2006) studied this question.
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