Key result
Early exposure of CD4+ T cells to IL-4 increased IL-4 mRNA stability via a HuR-mediated mechanism.
Early exposure to IL-4 stabilizes its own mRNA in CD4+ T cells through a HuR-mediated mechanism, revealing a positive feedback loop in T cell differentiation.
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Hypothesis-generating for HuR in Th2 regulation; leaves open targeted interventions in allergic disease.
Yarovinsky et al. (2006) studied this question. Early exposure to IL-4 was evaluated on IL-4 mRNA stability. Early exposure of CD4+ T cells to IL-4 increased IL-4 mRNA stability via a HuR-mediated mechanism.
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