Either glucagon or insulin, administered at pharmacological levels, increases rat liver tyrosine αa-ketoglutarate transaminase (TKT) activity, but only glucagon increases phenylalanine pyruvate transaminase (PPT) activity. Anti-insulin serum (AIS), which produces an acute diabetic condition when administered in large doses, elevates TKT but depresses PPT. When given to AlS-treated rats, exogenous glucagon further enhances TKT and reverses the repression of PPT. These results suggest that glucagon and insulin, under physiological conditions, may have mutually opposing actions in the regulation of these 2 liver transaminases. (Endocrinology 84: 381, 1969)
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Brown et al. (1969) studied this question.