The Churg Strauss Syndrome

During the first half of this century, several authors reported a variant of a small vessel vasculitis that appeared similar to the then recognized polyarteritis nodosa. The condition was distinguished by a significant atopic component, in the form of allergic rhinitis, bronchial asthma, and hypereosinophilia (1). Such patients frequently had a poor prognosis, with many patients dying as a result of cardiac complications, often within months of diagnosis. Although it has previously been called by several names including allergic angiitis and granulomatosis, it is now most commonly referred to as the Churg Strauss syndrome (CSS). Renal involvement in this condition is frequent although usually mild; however, an increasing number of case reports attest to the potential for severe renal disease to occasionally develop. Several lines of evidence suggest that CSS is not simply the coincidental development of vasculitis in patients with asthma. The asthma seen in CSS is notable for being of late onset; it is frequently severe and is associated with a greater degree of eosinophilia than is typically seen in bronchial asthma. There is often no personal or family history of atopic disease (2). In addition, cases are well described in which the asthma develops shortly before or simultaneously with vasculitis (3,4). The recognition of CSS as a separate disease entity is important, because its distinctive natural history (2,5), its frequent rapid response to treatment, and its good overall prognosis (4) suggest pathogenic mechanisms that differ either in nature or in degree compared with other forms of necrotizing vasculitis. Diagnosis The accurate diagnosis of CSS remains problematic. None of the disease features, either clinical or histologic, is on an individual level pathognomic of the condition. The syndrome is frequently phasic in nature, with the pathologic findings varying not only with the anatomical site examined but also with the phase of the illness (2). CSS classically develops as new onset asthma and/or allergic rhinitis, which progresses to hypereosinophilia, often with an associated tissue infiltration, before culminating in frank vasculitis. This sequential development of findings is not seen in all cases, and even when present the time course over which progression occurs can be highly variable. Therefore, rather than being dependent on any single symptom or pathologic finding at one time point, the accurate diagnosis of Churg Strauss syndrome requires the presence of a constellation of findings that may have presented and evolved over a period of years. Churg and Strauss in their original 1956 article outlined three pathologic features associated with the disease: an eosinophilic tissue infiltration, granuloma formation, and a necrotizing vasculitis involving small and medium-sized vessels (5). Eleven of the 13 patients they described had been studied by post mortem examination, and all had advanced disease without the benefit of effective treatment. Even so, only 10 of their 13 patients demonstrated all three pathologic features. Thus, it is not surprising that this triad of pathologic findings should yield a low sensitivity for the diagnosis of CSS, especially with the development of rapidly effective treatment and with histologic studies frequently limited to small volume biopsy specimens. To help overcome these limitations, Lanham et al. proposed a combined clinical and pathologic diagnostic scheme (Table 1) (2), and although the validity and accuracy of this scheme has never been assessed objectively, it has nonetheless been widely used. More recently, the American Rheumatology Association has proposed alternative diagnostic criteria for CSS (6). The presence of at least four of six findings (Table 1) was diagnostic of Churg Strauss, with a sensitivity of 85% and a specificity of 99.7% within the source population. However, these results have not as yet been validated in an independent sample of patients. The 1994 Chapel Hill consensus conference further defined CSS as an “eosinophil-rich and granulomatous inflammation involving the respiratory tract, and necrotizing vasculitis affecting small to medium sized vessels, and associated with asthma and eosinophilia” (7).Table 1: Diagnostic criteria for the Churg Strauss syndromeaAll of these classification systems and definitions have obvious limitations, especially in patients with mild or limited disease or in those who have already been started on therapy (8), especially as the peripheral hypereosinophilia of CSS responds rapidly to treatment with corticosteroids. Cases have also been reported that overall are suggestive of CSS but lack a typical feature of the syndrome such as asthma, even in the absence of prior treatment (9). These diagnostic difficulties highlight our need to better understand the underlying pathogenesis of the vasculitides to avoid being dependent on superficial overlapping clinical features for the purpose of diagnosis. Epidemiology CSS is global in its distribution and has no significant gender predilection. It occurs in all age groups, although it has been most commonly reported in the third through fifth decades of life. The mean (95% confidence interval) annual incidence of CSS in northern England between 1988 and 1994 was 2.4 (0.9 to 5.3) per million population. This incidence was 30% of that estimated for Wegener's granulomatosis and was similar to the incidence of microscopic polyangiitis (10). In a retrospective study from Norway, the estimated prevalence of CSS was 1.3 per 100,000 population, compared with 3.3 per 100,000 for polyarteritis nodosa and 5.3 for Wegener's granulomatosis (11). Clinical Features Prodromal Phase Allergic rhinitis is often the first evidence of disease (12) and occurs in up to 70% of cases. It is frequently severe and may be associated with nasal polyposis, obstruction, and recurrent sinusitis, but unlike Wegener's granulomatosis, the presence of nasal pain or frank hemorrhage is uncommon. Histologic examination usually reveals diffuse eosinophilia; upper airway granulomata are only rarely found. Asthma usually precedes the development of vasculitis by a period of weeks to years (3,4); it is often progressively severe and eventually requires oral steroids for adequate control. Eosinophilic tissue infiltration most commonly presents within the lungs as Loffler's pneumonia or less commonly in a more chronic relapsing form as chronic eosinophilic pneumonia. Gastrointestinal tract infiltration may present as eosinophilic gastroenteritis. Although these conditions are disease entities in their own right, they all form part of the spectrum of eosinophil-mediated disease, which may progress to a more generalized multisystem disease process in the form of CSS (12). Vasculitic Phase Systemic disease features during the vasculitic phase include weight loss, anemia, and fever. Rash occurs in up to 70% of cases and may include an erythematous maculopapular eruption, vasculitic ulcers, and/or subcutaneous nodules (3). Myalgia and a migratory nonerosive polyarthritis are common but are usually not severe. Pulmonary involvement represents a vasculitic process with a varying degree of eosinophilic infiltration. It may be associated with progressive dyspnea, alveolar hemorrhage (4), pleurisy, and the development of eosinophil-rich pleural transudates. Radiographic findings are generally nonspecific and, unlike Wegener's granulomatosis, cavitation rarely develops (3). Transbronchial biopsy revealed evidence of the disease in four of six cases studied by Schnabel et al., even in the absence of focal radiologic abnormality (13). Bronchial alveolar lavage usually reveals a normal total cell count, but with a dramatic increase in the percentage of eosinophils (mean 31%; range, 6 to 66%). Cardiac involvement is a common, although often late, manifestation of the disease. It was the primary cause of CSS-related death in the pre-corticosteroid era (2), and it still results in occasional fatalities despite modern treatment (3,4,9). Acute pericarditis may occur in up to one-third of cases and may be associated with pericardial effusion. Cardiac tamponade may develop and should be considered before initiating aggressive fluid removal with dialysis. Myocarditis may lead to postinflammatory fibrosis and congestive cardiac failure, while coronary vasculitis may result in ischemic heart disease. Gastrointestinal involvement is common and often severe, resulting in abdominal pain, ascites, diarrhea, and/or hematochezia (2,3,14). It resulted in 8% of the deaths reviewed by Lanham in his literature review (2). Involvement of vasa nervorum results in a mononeuritis multiplex and was found in 72% of cases in Guillevin's series and most commonly involved the common peroneal (84%) and the ulnar (55%) nerves (4). Cerebral vasculitis may predispose to hemorrhagic cerebrovascular events, especially in association with uncontrolled hypertension. Renal Disease Traditionally, renal involvement in CSS has been reported as being mild. In the pre-corticosteroid literature, early deaths due to cardiac disease may have limited the potential for widespread renal involvement, while the absence up until recently of widely accepted diagnostic criteria may also have resulted in many cases of CSS with a significant azotemic component being labeled as having an alternative diagnosis. As shown in Table 2, several series have reported a considerable degree of renal involvement. In Churg and Strauss' original report, they comment that mild hematuria and albuminuria were commonly present (5). Three of their 11 patients had azotemia and one died from uremia. Chumbley reported that the incidence of renal involvement was 20% (3). Six of his 30 patients had microscopic hematuria, three had slight elevations of serum urea and creatinine, and one died from renal failure. The incidence of proteinuria is not reported and no renal biopsies were performed. Lanham et al., in his literature review, found 49% of cases to have mild or moderate renal involvement and renal failure in 9% (2). Renal failure was second only to cardiac disease as a cause of death (occurring in 18% of recorded fatalities). In the most recent and largest individual case series by Guillevin et al., 25 of 96 patients (26%) had proteinuria with levels in excess of 1 g/d. Five patients are reported as having renal insufficiency, although the degree of azotemia is not provided, and eight patients were diagnosed as having glomerulonephritis (4).Table 2: Renal involvement in the Churg Strauss syndromeaClutterbuck et al., reviewing the results at Hammersmith Hospital, reported that renal disease was present in 16 of 19 patients with CSS and was frequently severe (15). This high incidence of severe renal involvement may partly reflect referral bias; however, only five of the 16 patients were referred from other hospitals. Microscopic hematuria was present in 13 patients, granular casts in nine, and red cell casts in three. Twelve patients had proteinuria, with three patients having an established nephrotic syndrome. Four cases presented with a serum creatinine >500 μmol/L (5.6 mg/dl), two being dialysis-dependent from the time of presentation. A similar potential for severe renal involvement is also shown by numerous recent case reports (16,17,18,19,20,21,22). The presence or absence or absence of azotemia therefore does not reliably distinguish CSS from other forms of renal necrotizing vasculitis. Renal histology may on occasion reveal frank vasculitis (Figure 1). Vasculitis involving arteries of varying sizes was found in seven of the 13 cases in the Churg autopsy series (5) and in two of the 19 subjects in Clutterbuck's biopsy series (15). These resembled the changes found in other necrotizing vasculitides but are distinguished, at least before treatment, by a widespread infiltration of activated eosinophils. As in any necrotizing vasculitis, there may be destruction of the internal elastic membrane and aneurysm formation, as demonstrated in one of eight angiograms in Clutterbuck's report (15) and in nine of 30 in that of Guillevin (4). The more typical histologic finding by percutaneous renal biopsy is a focal segmental (Figure 2) or a diffuse necrotizing (Figure 3) glomerulonephritis. This frequently occurs in the setting of an intense eosinophil-rich interstitial infiltrate (Figure 2). Churg described these glomerular changes as usually being mild and affecting only a minority of glomeruli (5). However, in the Hammersmith series of 13 renal biopsy specimens, 11 showed focal glomerulonephritis, with necrotizing features present in eight and crescents in nine (15).Figure 1.: Polyarteritis-like segmental necrosis and inflammation of a medium-sized artery from the mesentery. This case had no renal involvement. Hematoxylin and eosin stain, ×100.Figure 2.: A small area of segmental glomerular necrosis from a renal biopsy with the pattern of focal necrotizing glomerulonephritis and 10% glomerular involvement. Also note the intense interstitial inflammatory cell infiltrate, which in this case contains numerous eosinophils. Hematoxylin and eosin stain, ×200.Figure 3.: Extensive glomerular necrosis from a renal biopsy showing the pattern of diffuse necrotizing and crescentic glomerulonephritis with 80% glomerular involvement. Hematoxylin and eosin stain, ×200.Interstitial changes usually consist of edema and a diffuse eosinophilic infiltrate with associated lymphocytes, neutrophils, and plasma cells, and on occasion may be associated with only minimal glomerular pathology (15,23). Interstitial granulomata, usually with a core of degenerating eosinophils and situated adjacent to a venule, as described in Churg and Strauss' original autopsy series (5), have since only rarely been described in renal biopsy specimens (2). Tubular changes are usually mild and nonspecific. Immunofluorescence microscopy has revealed only nonspecific staining in areas of segmental necrosis, while electron microscopy typically reveals the absence of dense deposits. In addition to intrinsic renal disease, renal dysfunction may also result from an obstructive uropathy due to vasculitic involvement of the ureters and the lower genito-urinary tract. Chumbley et al. described granulomatoid involvement of the prostate in three patients (3), with one of the three patients presenting with obstructive uropathy. In Churg and Strauss' original series, one patient had thickened nodular dilated ureters (5), and several case reports have confirmed the potential for ureteric vasculitis with an associated stenosis and obstruction (4,24,25,26). Laboratory Findings Typical laboratory findings in CSS include a normochromic normocytic anemia, leukocytosis, and an acute-phase response with elevated erythrocyte sedimentation rate and C-reactive protein levels. In the series by Lanham et al., the peak eosinophil count varied from 1,500 to 29,000 × 106/L. In the same study, six of eight patients in whom levels were measured had elevated Ig E levels (2). Low levels of circulating IgE immune complexes, rheumatoid factor (2,3), and antinuclear antibodies (4) have also occasionally been described, but in most cases appear to be nonspecific. Measurements of complement, cryoglobulin, and infectious hepatitis serology are usually unremarkable. Anti-Cytoplasmic Neutrophil Antibodies An analysis of the association between CSS and anti-cytoplasmic neutrophil antibodies (ANCA) is difficult, because various studies have used different diagnostic criteria for CSS, as well as varied methods in the performance and interpretation of ANCA assays. Approximately one-half to two-thirds of reported patients with CSS are ANCA-positive. Individual studies have found ANCA in seven of 17 (41%) (27), 20 of 42 (47%) (4), 10 of 17 (58%) (9), six of nine (60%) six of nine (60%) nine of and 11 of 13 patients A small number of have widely on various of ANCA in CSS and in other to the of CSS, many different reports that to CSS in different from individual are on the same small number of patients. As a there is a considerable degree of in the To help overcome this have the single most report from that to ANCA in three or more patients with CSS and of CSS to a of staining by however, as shown in Table the presence of a staining pattern is not uncommon. this in the of to staining in different studies in diagnostic or other potential such as or is not specificity by have shown a of antibodies in subjects with Several patients have been described who showed a staining pattern by but who to the usually associated with the these patients have an alternative ANCA other than the or these results reflect the difficulties in is results in the Churg Strauss in the Churg Strauss The of CSS is to because evidence of the initiating may no be present by the time the disease clinical Several authors have in this condition and in Wegener's for this from case reports of CSS and to (4), as well as a proposed of cases of Guillevin et al. reported patients as having with a of and four as having been in the period before CSS being diagnosed (4). CSS has also been described in association with and the However, the are or the result of by with early patients to the treatment, is the and and interstitial edema formation, but it does not the spectrum of of corticosteroids. treatment with steroids had been for asthma, associated with CSS, then the of steroids by well be to be associated with an increase in the underlying disease and with the diagnosis of The pathogenic of ANCA antibodies in the development of CSS is absence in one-third of patients that at least in their described they are not a for the presence of the syndrome. In addition, the presence of ANCA has been shown to be associated with a disease feature or in The feature of CSS is an small vessel The degree of eosinophil infiltration is in excess of that seen in inflammatory et al. were to that activated eosinophils and eosinophil were present within vessel and granulomata Several authors have been to a between the eosinophil level eosinophil and CSS disease The of eosinophil-mediated disease has recently been reviewed the of CSS, it is that activated eosinophils are to cell As in other inflammatory this on the of a of The may an in this the of the and and eosinophil to activated its may be for et al. in the of a patient with a severe renal eosinophilic interstitial infiltrate but not from patients with the hypereosinophilia syndrome but no renal disease The level in addition with the original disease The eosinophil may also be for of the disease features of CSS, by of the of its such as eosinophilic which is in the that is seen in CSS and in the hypereosinophilia and which may to the development of peripheral CSS frequently responds rapidly to (4). of various and the of eosinophil in In the Hammersmith several patients with azotemia but with serum creatinine levels μmol/L on were with The creatinine level to normal in all patients, despite four having crescentic disease associated with necrotizing features on biopsy authors the of either by the oral or in all patients with CSS, a for other necrotizing vasculitides (12). for this is the that by the time it is that steroids are the disease, significant tissue may already have although the with which this occurs is in patients is to be to due to in or to in This may partly the response of patients to steroids and that it is this that benefit most from Although the of has in other forms of necrotizing vasculitis, these may not be in patients with In in patients, the potential of may any of its is also a of eosinophil It has recently been reported to in four patients with aggressive disease, two of whom had an treatment with steroids and and have also been used in an setting in CSS, although their in disease treatment remains A potential of treatment is the development of antibodies such as The a for such an as a result of its for eosinophils The only clinical of treatment of CSS has been by the however, interpretation of their findings is limited because their studies include patients with CSS, polyarteritis and microscopic results are not by the underlying diagnosis. found that for this the of in addition to steroids not but appear to result in of disease and better of The addition of with either steroids or combined treatment with steroids and not appear to any the prognosis for CSS to be good Guillevin et al. reported a rate of with an clinical being in of patients (4). of 96 patients from a total of which were in most cases by an in serum eosinophil levels. three patients from of the patients who to an increase in However, four patients to and died (4). In the Hammersmith six of 16 patients four of these were by a in and only one patient from (2). The renal prognosis is also In the Hammersmith series, three of four patients who presented with advanced azotemia independent the had evidence of chronic on biopsy and to to therapy In the Guillevin series, no patient was recorded as from a renal (4). analysis of the presenting features of the 96 patients reported by Guillevin showed that cardiac and but not involvement were associated with a poor the of disease usually either to the of during the vasculitic phase or to of the Asthma may and while progressive heart failure may also is often a frequent and The Churg Strauss is an small vessel vasculitis. Although its pathogenesis may be distinctive and the association with severe asthma the clinical features during the vasculitic phase widely with those of the other forms of necrotizing vasculitis, and no single clinical or histologic feature is pathognomic of the condition. Renal involvement is common, although usually and even when severe it to well to treatment. The prognosis for patient and renal with adequate treatment is in The treatment however, is and may differ from that for the other In in to Wegener's granulomatosis, the need for treatment is and requires further was by of Renal Disease Epidemiology The authors for his review of this