A Novel BRCA2-Binding Protein and Breast and Ovarian Tumorigenesis

A fundamental question of cancer genetics is how genes responsible for inherited cancer contribute to the far more frequent cases of cancer that are purely somatic in origin. Somatic mutations in p53 in a vast range of tumors are similar to inherited germ-line mutations in the p53 tumor-suppressor gene in families with the Li–Fraumeni syndrome and were discovered at about the same time. But the roles of other inherited cancer genes in somatic tumorigenesis have been more difficult to define. Biochemistry has come to the rescue of genetics in this effort. Binding partners of the proteins encoded by cancer genes . . .