Synthesis of N‐acetyl‐muramyl‐l‐alanyl‐d‐isoglutamine, an Adjuvant of the Immune Response, and of Some N‐acetyl‐muramyl‐peptide Analogs

A relatively easy synthetic method is reported for the production of the immunoadjuvant glycopeptide, N-acetyl-muramy-L-alanyl-D-isoglutamine (MDP). Most of the details in this method were also applied to the preparation of some analogs, that were synthesized in order to study structure-activity relationships.