Liquid chromatography has been investigated as a means of rapidly determining hexachlorodibenzo-ρ-dioxin and octa-chlorodibenzo-ρ-dioxin in pentachlorophenol. The non-phenolic impurities are quantitatively isolated from the sample matrix by an extraction-ion exchange procedure that permits the chlorinated dibenzo-ρ-dioxins to be determined by liquid chromatography. The sample concentrates are analyzed by reverse-phase partition chromatography in a forty-minute separation using an isocratic mobile phase. A sample may be analyzed in four hours with detection limits of 0.2 ppm for hexachlorodibenzo-ρ-dioxin and 0.1 ppm for octachlorodibenzo-ρ-dioxin. This technique was used as a means of rapidly examining the nonphenolic impurities in commercial pentachlorophenol from various domestic sources.
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C. D. Pfeiffer (1976) studied this question.