Key result
Higher plasma levels of TIMP-1 were independently associated with myocardial diastolic dysfunction, including E/E' and diastolic function reserve index, in patients with Type 2 diabetes mellitus.
Why the study?
Are extracellular matrix biomarkers associated with myocardial diastolic dysfunction in patients with Type 2 diabetes mellitus?
Observational
Are extracellular matrix biomarkers associated with myocardial diastolic dysfunction in patients with Type 2 diabetes mellitus?
TIMP-1 levels are independently associated with echocardiographic markers of myocardial diastolic dysfunction in patients with Type 2 diabetes mellitus, highlighting the potential role of extracellular matrix remodeling in diabetic cardiomyopathy.
AIM: The study evaluated the relationship of extracellular matrix and renin angiotensin system with myocardial dysfunction in Type 2 diabetes mellitus. METHODS: All patients underwent resting and exercise echocardiography, including conventional parameters, E/E' ratio, global longitudinal strain and diastolic function reserve index. Plasma matrix metalloproteinase-1, TIMP-1, amino-terminal propeptide of type I and type III procollagen and renin angiotensin system activity were measured. RESULTS: As patients with diastolic dysfunction had a higher plasma level of TIMP-1 and propeptide of type III procollagen than those with no diastolic dysfunction. After multivariate adjustment, TIMP-1 associated with E/E' (both at rest and stress) and diastolic function reserve index. CONCLUSION: TIMP-1 is independently associated with myocardial diastolic dysfunction in patients with Type 2 diabetes mellitus.
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Liu et al. (2017) conducted an observational in Type 2 diabetes mellitus. Extracellular matrix biomarkers (TIMP-1 and propeptide of type III procollagen) vs. Lower biomarker levels / No diastolic dysfunction was evaluated on Myocardial diastolic dysfunction (E/E' ratio and diastolic function reserve index). Higher plasma levels of TIMP-1 were independently associated with myocardial diastolic dysfunction, including E/E' and diastolic function reserve index, in patients with Type 2 diabetes mellitus.
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