Born to be mild: The general, direct and selective C2 arylation of native Trp-containing peptides can be achieved by palladium-catalyzed CH activation with aryl iodides in water, under microwave irradiation for a short time (see scheme). Under these mild conditions, the structural and stereochemical integrity of peptides is preserved.
No takes yet. Share an insight, caveat, or question.
Ruiz‐Rodríguez et al. (2009) studied this question.