Copper‐Mediated Difluoromethylation of (Hetero)aryl Iodides and β‐Styryl Halides with Tributyl(difluoromethyl)stannane

Owing to their unique properties, molecules containing the difluoromethyl group (CF2H) are of great interest. Tributyl(difluoromethyl)stannane has now been used for the selective and efficient direct ipso difluoromethylation of aryl iodides, heterocyclic iodides, and β-styryl halides (see scheme). The straightforward preparation of the difluoromethylating reagent makes this approach particularly valuable.