Optimisation of electron-induced dissociation parameters for molecular annotation of glycerides and phospholipids in fast LC-MS

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Optimized electron-induced dissociation (EIEIO) parameters enable the determination of sn-position and double bond locations in fatty acyl chains of glycerides and phospholipids within typical fast LC-MS timescales (~0.2 s). Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Vincen Wu; Abraham Moyal; Alaa Othman; Nicola Zamboni

doi:10.1039/d5an00567a

January 1, 2025The AnalystOpen Access

Optimisation of electron-induced dissociation parameters for molecular annotation of glycerides and phospholipids in fast LC-MS

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Abstract

-position and double bond locations in fatty acyl chains, is achievable within typical LC-MS timescales (∼0.2 s). Our findings outline practical guidelines for high-throughput analysis of complex lipid samples by EIEIO.

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Wu et al. (2025) studied this question.

synapsesocial.com/papers/6a6e54f8e36a167817e0736a https://doi.org/10.1039/d5an00567a

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Optimisation of electron-induced dissociation parameters for molecular annotation of glycerides and phospholipids in fast LC-MS

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Optimisation of electron-induced dissociation parameters for molecular annotation of glycerides and phospholipids in fast LC-MS

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