Leg oxygen uptake (V̇o 2 ) peak, ventilatory efficiency (V̇E/V̇co 2 ratio), and substrate utilization were measured during functional electrical stimulation cycling FES-LEC testing following 12–16 wk of either electrically evoked resistance training or passive movement training; indirect calorimetry and mitochondrial complex levels in muscle biopsies were also determined. FES-LEC increased thigh muscle area and leg V̇o 2 peak increased but decreased V̇E/V̇co 2 ratio; there were no changes in mitochondrial complex levels. Leg V̇o 2 peak was associated with hypertrophy of the paralyzed muscles and mitochondrial respiration of complex I following training.
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Gorgey et al. (2021) studied this question.
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