Key result
Weight loss-induced increases in adiponectin correlated positively with free testosterone (r=0.320, p=0.013) and inversely with carotid intima-media thickness (r=-0.283, p=0.028) in men.
Why the study?
The study aimed to evaluate adiponectin changes after metabolic surgery in men with versus without male-obesity-associated secondary hypogonadism, and examine their association with cardiovascular risk measured by carotid intima-media thickness.
Does weight loss improve adiponectin and reduce cIMT in men with male-obesity-associated secondary hypogonadism?
Cohort (n=60)
Does weight loss improve adiponectin and reduce cIMT in men with male-obesity-associated secondary hypogonadism?
Effect estimate: r = -0.283
p-value: p=0.028
Resolution of male-obesity-associated secondary hypogonadism after weight loss is associated with increased adiponectin and decreased carotid intima-media thickness.
APN rise after surgery may link to vascular benefits in MOSH; leaves open whether it mediates hypogonadism resolution.
Male-obesity-associated secondary hypogonadism (MOSH) is a very prevalent entity that may resolve after marked weight loss. Adiponectin (APN) is an adipokine with anti-inflammatory properties that regulates metabolism. Low-circulating APN is associated with obesity, diabetes, and cardiovascular risk, along with circulating testosterone. We aimed to evaluate APN changes in men with MOSH (low circulating free testosterone (FT) with low or normal gonadotropins) and without it after metabolic surgery. We look for their possible association with cardiovascular risk measured by carotid intima-media thickness (cIMT). We included 60 men (20 submitted to lifestyle modification, 20 to sleeve gastrectomy, and 20 to gastric bypass) evaluated at baseline and 6 months after. The increase in APN at follow-up was reduction in patients with persistent MOSH (n = 10) vs. those without MOSH (n = 30) and MOSH resolution (n = 20), and the former did not achieve a decrease in cIMT. The increase in APN correlated positively with FT (r = 0.320, p = 0.013) and inversely with cIMT (r = −0.283, p = 0.028). FT inversely correlated with cIMT (r = −0.269, p = 0.038). In conclusion, men without MOSH or with MOSH resolution showed a high increase in APN after weight loss with beneficial effects on cIMT. Those without MOSH resolution failed to attain these effects.
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Cobeta et al. (2022) conducted a cohort in Male-obesity-associated secondary hypogonadism (MOSH) (n=60). Weight loss interventions (lifestyle modification, sleeve gastrectomy, or gastric bypass) vs. Persistent MOSH was evaluated on Correlation between increase in adiponectin and carotid intima-media thickness (cIMT) (r = -0.283, p=0.028). Weight loss-induced increases in adiponectin correlated positively with free testosterone (r=0.320, p=0.013) and inversely with carotid intima-media thickness (r=-0.283, p=0.028) in men.
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