Key result
Iomeprol 400 was safe and well tolerated in patients with renal impairment and end-stage renal disease, with approximately 58% of the dose recovered in dialysate after a single session.
Why the study?
What are the pharmacokinetics and safety of a single intravenous dose of iomeprol 400 in healthy volunteers and patients with varying degrees of renal impairment?
Population
30 subjects of either sex, including 6 healthy volunteers with normal renal function, 6 patients with mild…
Design
Cohort, open-label
Follow-up
up to 10 days
Authors
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May support use in renal impairment; leaves open need for larger comparative trials.
What are the pharmacokinetics and safety of a single intravenous dose of iomeprol 400 in healthy volunteers and patients with varying degrees of renal impairment?
Iomeprol is effectively eliminated by dialysis and requires no dose adjustment in patients with renal impairment or end-stage renal disease.
Lorusso et al. (2001) studied Renal impairment or end-stage renal disease requiring hemodialysis (n=30). Iomeprol 400 was evaluated on Pharmacokinetics and safety. Iomeprol 400 was safe and well tolerated in patients with renal impairment and end-stage renal disease, with approximately 58% of the dose recovered in dialysate after a single session.