Key result
High-energy feeding supplemented with glucose polymer significantly increased mean weight gain from 1.3 to 5.8 g/kg per day in infants with congenital heart disease and failure to thrive.
Why the study?
Does high-energy feeding improve energy retention and weight gain in infants with congenital heart disease and failure to thrive?
Does high-energy feeding improve energy retention and weight gain in infants with congenital heart disease and failure to thrive?
Absolute Event Rate: 5.8% vs 1.3%
p-value: p=<0.001
High-energy feeding supplemented with glucose polymer significantly improves weight gain and energy retention in infants with congenital heart disease and failure to thrive without significantly increasing resting oxygen consumption.
May support glucose polymer supplementation for weight gain in congenital heart disease infants; leaves open confirmation in randomized trials.
Failure to thrive (FTT) in infants with congenital heart disease (CHD) can be attributed to their low energy intakes and high resting energy expenditures. Energy intake, energy expenditure and growth were studied in infants with CHD on normal formula feeds and then on feeds supplemented with glucose polymer to see whether supplementation improved energy retention and growth. Mean gross energy intakes increased by 31.7% on high-energy feeding and mean weight gain improved from 1.3 g/kg per d on control to 5.8 g/kg per d on high-energy feeding. Resting oxygen consumption (VO2 ml/kg per min) was not significantly different on the two feeding regimens, although respiratory quotient rose on high-energy feeding reflecting the increased carbohydrate intake. Estimated energy costs of growth on high-energy feeding fell within the previously described range for normal infants. It is recommended that infants with CHD known to be associated with FTT are fed on high-energy diets from the time of diagnosis in order to optimize growth.
No takes yet. Share an insight, caveat, or question.
Jackson et al. (1991) studied Congenital heart disease and failure to thrive (n=14). High-energy feeding (glucose polymer supplementation) vs. Standard infant formula was evaluated on Mean weight gain (g/kg per day) (p=<0.001). High-energy feeding supplemented with glucose polymer significantly increased mean weight gain from 1.3 to 5.8 g/kg per day in infants with congenital heart disease and failure to thrive.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: