The Involvement of Serum Amyloid A in Psoriatic Inflammation

Psoriasis vulgaris is a common inflammatory skin disorder that is characterized by abnormal epidermal proliferation and a cellular infiltrate including neutrophils and T cells (Nestle et al., 2009). The number of T helper (Th) type 1 and Th17 cells are particularly increased in psoriatic patients, and they are thought to play critical roles in the pathogenesis (Lowes et al., 2013; Nestle et al., 2009). In addition, psoriatic keratinocytes are morphologically abnormal and may influence infiltrating T-cell function by producing cytokines and chemokines (Lowes et al., 2013; Nestle et al., 2009).