Effect of Choline and Methionine, Testosterone Propionate, and Dietary Protein on Nitrogen Balance in Patients With Liver Disease 12

Choline and methionine have been administered as therapeutic agents to patients with liver dis- ease on the basis of demonstrated beneficial ef- fects of these agents in the dietary cirrhosis of animals (1-6). The therapeutic value of such specific agents in human liver disease is difficult to assess clinically, by tests of liver functions, or by biopsy of the liver, because of the naturally oc- curring variations in the nature, severity, and course of the disease.