Key result
In a real-world Korean registry, 36.4% of patients with atrial fibrillation were prescribed an off-label reduced dose of NOACs, which was associated with older age, female sex, and lower body weight.
Why the study?
Label adherence for NOACs had not been well evaluated in Asian patients with non-valvular AF.
Population
3080 AF patients treated with NOACs in Korea
Comparison
On-label vs off-label NOAC dosing
Design
Prospective registry-based cohort study
Authors
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Off-label reduced NOAC dosing common in Korean AF; hypothesis-generating for stroke risk, needs prospective validation.
Cohort (n=3,080)
Yes
In real-world practice, over one-third of Asian patients with atrial fibrillation receive off-label underdosed NOACs, highlighting a significant gap in guideline-directed anticoagulation.
Lee et al. (2019) conducted a cohort in Atrial fibrillation (n=3,080). Non-vitamin K antagonist oral anticoagulants (NOACs) was evaluated on Off-label reduced dose prescription (underdosing). In a real-world Korean registry, 36.4% of patients with atrial fibrillation were prescribed an off-label reduced dose of NOACs, which was associated with older age, female sex, and lower body weight.
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