Key result
VEGF-B deficiency causes atrial conduction abnormalities characterized by prolonged PQ intervals in adult mice.
Why the study?
The physiological function of VEGF-B, expressed in many tissues including the heart, was still unknown.
Does targeted deletion of the VEGF-B gene affect heart function or angiogenesis in mice?
Does targeted deletion of the VEGF-B gene affect heart function or angiogenesis in mice?
VEGF-B is required for normal atrial conduction in adult mice but not for cardiovascular development or adult angiogenesis.
No takes yet. Share an insight, caveat, or question.
VEGF-B loss prolongs PQ interval in mice; leaves open any human atrial conduction role pending translational studies.
Aase et al. (2001) studied this question. VEGF-B gene deletion vs. Normal mice was evaluated on Atrial conduction abnormality (prolonged PQ interval). VEGF-B-deficient mice displayed an atrial conduction abnormality characterized by a prolonged PQ interval, indicating VEGF-B is required for normal heart function in adult animals.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: