Key result
Pentobarbital raises the threshold for venous air emboli transpulmonary passage vs halothane in dogs.
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The influence of halothane, pentobarbital, and their interaction on the passage of air across the pulmonary circulation was studied in 12 dogs using transesophageal M-mode echocardiography for air detection in the left atrium and/or aorta. Air was detected in the left atrium and/or aorta after pulmonary artery air injection of 0.04 ml/kg during 1% halothane anesthesia (n = 5). Addition of pentobarbital changed the threshold to 1.0 ml/kg. During pentobarbital anesthesia with and without halothane (n = 7), the thresholds were 1.1 and 1.2 ml/kg, respectively. The authors conclude that the threshold for transpulmonary passage of venous air is higher during anesthesia with pentobarbital with or without halothane than during anesthesia with halothane alone.
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Yahagi et al. (1987) studied Venous air emboli (n=12). Halothane vs. Pentobarbital was evaluated on Threshold of transpulmonary passage of venous air emboli. Anesthesia with pentobarbital resulted in a higher threshold for transpulmonary passage of venous air (1.1-1.2 ml/kg) compared to halothane alone (0.04 ml/kg) in dogs.
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