Key result
One-third of prostate cancer survivors reported high fear of recurrence at 4.1 years, with higher scores among active surveillance patients and radical prostatectomy patients with treatment failure.
Why the study?
Little is known about the prevalence of fear of recurrence across different treatment groups and factors associated with it among prostate cancer survivors.
What is the prevalence of high fear of recurrence among prostate cancer survivors after radical prostatectomy or under active surveillance, and what factors are associated with it?
Cross-Sectional (n=440)
Yes
What is the prevalence of high fear of recurrence among prostate cancer survivors after radical prostatectomy or under active surveillance, and what factors are associated with it?
High fear of recurrence is common among prostate cancer survivors 4 years post-diagnosis, particularly in those under active surveillance or with treatment failure after radical prostatectomy.
BACKGROUND: Fear of recurrence (FoR) is a distressing consequence of cancer. Little is known about the prevalence of FoR in different treatment groups and factors associated with FoR among prostate cancer (PCa) survivors. OBJECTIVE: To investigate the prevalence of high FoR among PCa survivors after radical prostatectomy (RP) or under active surveillance (AS) and to explore clinical and psychological factors potentially associated with FoR. DESIGN SETTING AND PARTICIPANTS: = 164) at two Norwegian regional hospitals. The 440 patients (73%) who gave consent to participate were invited in 2017 to complete a questionnaire measuring FoR, self-rated health, adverse effects, and psychological factors at a mean of 4.1 yr (standard deviation 1.7) after their treatment decision. Clinical data were retrieved from medical records. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: FoR was measured using the Concerns About Recurrence Questionnaire, with high FoR defined as a sum score of =12 points (range 0-40). Using multivariable logistic regression analyses, factors associated with high FoR were identified. RESULTS AND LIMITATIONS: One-third of the participants had high FoR; scores were higher in the AS group and in the RP group with treatment failure. Younger age was significantly associated with high FoR in the AS group, while high prostate-specific antigen at diagnosis, biochemical recurrence, positive surgical margin, higher fatigue, and a type D personality were significantly associated with high FoR in the RP group. CONCLUSIONS: At 4 yr after a diagnosis of PCa, high FoR was common, especially among AS patients and among RP patients with treatment failure. PATIENT SUMMARY: In this study, we examined fear that their disease will return or progress among prostate cancer survivors. We found that such fear was common, especially among young patients under active surveillance and among radical prostatectomy patients with treatment failure or with certain psychological features.
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Nilsson et al. (2021) conducted a cross-sectional in Prostate cancer (n=440). Active surveillance vs. Radical prostatectomy was evaluated on High fear of recurrence (Concerns About Recurrence Questionnaire score ≥12). One-third of prostate cancer survivors reported high fear of recurrence at 4.1 years, with higher scores among active surveillance patients and radical prostatectomy patients with treatment failure.
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