Evidence for the intermediate in the polyether biosynthesis of the ionophore antibiotic monensin A has been obtained. A tridecaketide E,E,E-triene (see formula) has been isolated by using mutant strains of Streptomyces cinnamonensis. Characterization of this intermediate allows the likely biosynthetic route to monensin to be discriminated.
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Bhatt et al. (2005) studied this question.
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