Key result
The 20210 G-->A mutation in the prothrombin gene was associated with an increased risk of myocardial infarction (RR 4.2; 95% CI 1.2-14.6) and elevated markers of thrombin generation.
Why the study?
Does the 20210 G-->A mutation in the prothrombin gene increase the risk of myocardial infarction and arterial thrombotic disease?
Case-Control (n=663)
Does the 20210 G-->A mutation in the prothrombin gene increase the risk of myocardial infarction and arterial thrombotic disease?
Relative Risk: 4.2 (95% CI 1.2–14.6)
The 20210 G-->A mutation in the prothrombin gene is a genetic risk factor for myocardial infarction and is associated with excessive thrombin generation.
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No association found with premature atherosclerotic disease; leaves open the 20210A variant's role in arterial thrombosis.
Franco et al. (1999) conducted a case-control in Premature atherosclerotic disease (n=663). 20210 G-->A mutation in the prothrombin gene vs. Non-carriers was evaluated on Myocardial infarction (RR 4.2, 95% CI 1.2-14.6). The 20210 G-->A mutation in the prothrombin gene was associated with an increased risk of myocardial infarction (RR 4.2; 95% CI 1.2-14.6) and elevated markers of thrombin generation.
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