A new phenone from the roots of Paeonia suffruticosa Andrews

Liqin Dinga#, Qingfei Zuoa#, Dandan Lia, Xinchi Fengb, Xiumei Gaoa, Feng Zhaoc* & Feng Qiuab*a Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, Chinab School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, Chinac School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China* Corresponding author. Email: ytuzhaofeng@163.com (F. Zhao)** Email: fengqiu20070118@163.com (F. Qiu)# Liqin Ding and Qingfei Zuo contributed equally to this work.AbstractThirteen phenones were obtained from the 70% ethanol extract of Paeonia suffruticosa Andrews. Their structures were determined on the basis of chemical methods and spectral data. Among them, compound 1 was identified as a new compound, and compounds 5 and 13 were obtained from genus Paeonia for the first time. The inhibitory effects of isolated compounds (1–12) on nitric oxide (NO) production in lipopolysaccharide-activated macrophages were evaluated, and NO production was suppressed significantly by compound 7.