Cross-sectional study evaluates bone turnover markers and mineral metabolism in kidney transplant recipients, indicating unique bone remodeling profiles.
Key Points
This study aims to investigate the relationship between bone turnover markers and bone density in kidney transplant recipients compared to non-transplanted individuals.
Cross-sectional comparative study involving 50 kidney transplant recipients and 56 non-transplanted individuals.
Quantification of serum bone markers using enzyme-linked immunosorbent assay (ELISA) and dual-energy X-ray absorptiometry (DXA) for bone mineral density.
Exploratory receiver operating characteristic (ROC) analysis to assess associations of bone turnover markers with kidney transplant status.
Kidney transplant recipients exhibited lower DXA-derived Z-scores at hip and lumbar spine compared to the reference group.
Adjusted differences indicated higher BALP (129.96 ng/mL, p < 0.001) in KTRs with no significant changes in P1NP and lumbar spine BMD.
BALP displayed the strongest separation between groups in ROC analysis (AUC = 0.808, p < 0.001).