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August 2, 2026International Journal of Neural Systems

Neuroimaging Biomarkers for Brain Disorder Diagnosis Using Advanced Learning Techniques

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Authors

IIIulia-Andreea IonCCCamelia Chira

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Overview

Randomized trial evaluates neuroimaging biomarker accuracy in brain disorders, suggesting optimal preprocessing strategies for diagnosis.

Key Points

  • This study aims to identify neuroimaging biomarkers and assess the impact of preprocessing techniques on fMRI data for diagnosing mental disorders.
  • Used resting-state fMRI data for analysis of functional connectivity in Bipolar Disorder and Alzheimer’s Disease.
  • Applied two preprocessing pipelines: one combining Statistical Parametric Mapping with the CONN toolbox and another using the MELODIC software.
  • Employed Support Vector Machines, Random Forests, and the Deep Learning model AlexNet for classification tasks.
  • Connbox-SPM preprocessing with AlexNet achieves 78.2% accuracy in Bipolar Disorder.
  • Connbox-SPM preprocessing with AlexNet reaches 82.4% accuracy in Alzheimer’s Disease.
  • Preprocessing choices significantly influence classification performance and functional connectivity representation.

Cite This Study

Ion et al. (2026) studied this question.

synapsesocial.com/papers/6a6eeaf51b0468a7eeab3ac1https://doi.org/10.1142/s0129065727500158
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