Key result
A standardized hyperventilation maneuver significantly increased periodic repolarization dynamics compared to baseline (3.30 vs. 2.76 deg^2, p=0.018) in healthy adults.
Why the study?
Heart and lung interaction is mediated by the autonomic nervous system, but methods to assess autonomic activity within cardiorespiratory coupling are lacking.
Does a standardized hyperventilation maneuver increase periodic repolarization dynamics (PRD) in healthy subjects?
Does a standardized hyperventilation maneuver increase periodic repolarization dynamics (PRD) in healthy subjects?
Hyperventilation significantly increases periodic repolarization dynamics, an ECG-based biomarker of sympathetic activity, independent of heart rate.
PRD may mark sympathetic repolarization effects during hyperventilation in healthy subjects; leaves open validation in clinical cardiorespiratory cohorts.
Heart and lung function are closely connected, and the interaction is mediated by the autonomic nervous system. Hyperventilation has been demonstrated to especially activate its sympathetic branch. However, there is still a lack of methods to assess autonomic activity within this cardiorespiratory coupling. Periodic repolarization dynamics (PRD) is an ECG-based biomarker mirroring the effect of efferent cardiac sympathetic activity on the ventricular myocardium. Its calculation is based on beat-to-beat variations of the T-wave vector (dT°). In the present study we investigated the effects of a standardized hyperventilation maneuver on changes of PRD and its underlying dT° signal in 11 healthy subjects. In response to hyperventilation dT° revealed a characteristic pattern and normalized dT° values increased significantly compared to baseline (0.063 (IQR 0.032) vs. 0.376 (IQR 0.093), p<0.001) and recovery (0.082 (IQR 0.029) vs. 0.376 (IQR 0.093), p<0.001). During recovery dT° remained on a higher level compared to baseline (p=0.019). When calculating PRD, we found significantly increased PRD values after hyperventilation compared to baseline (3.30 (IQR 2.29) deg2 vs. 2.76 (IQR 1.43) deg2; p=0.018). Linear regression analysis revealed that the increase in PRD level was independent of heart rate (p = 0.63). Our pilot data provides further insights in the effect of hyperventilation on sympathetic activity associated repolarization instability.
No takes yet. Share an insight, caveat, or question.
Schüttler et al. (2020) studied Healthy (n=11). Standardized hyperventilation maneuver vs. Baseline (resting phase) was evaluated on Periodic repolarization dynamics (PRD) (p=0.018). A standardized hyperventilation maneuver significantly increased periodic repolarization dynamics compared to baseline (3.30 vs. 2.76 deg^2, p=0.018) in healthy adults.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: