What question did this study set out to answer?

This research aims to understand how irradiation of fibroblasts influences the migration of head and neck squamous cell carcinoma (HNSCC) cells through interleukin-6 (IL-6) secretion.

January 28, 2022PLoS ONEOpen Access

Irradiated fibroblasts increase interleukin-6 expression and induce migration of head and neck squamous cell carcinoma

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This research aims to understand how irradiation of fibroblasts influences the migration of head and neck squamous cell carcinoma (HNSCC) cells through interleukin-6 (IL-6) secretion.
Utilized head and neck squamous cell carcinoma cell lines SAS and FaDu and fibroblast cell lines.
Performed irradiation on fibroblasts and HNSCC cells, measuring cell viability and IL-6 levels using ELISA.
Conducted migration assays comparing HNSCC cell movement in coculture with irradiated and nonirradiated fibroblasts.
Irradiation reduced HNSCC cell survival, while fibroblasts were resistant to irradiation.
Irradiated fibroblasts enhanced IL-6 secretion and further promoted HNSCC cell migration.
IL-6 neutralizing antibody abolished the enhanced migration of HNSCC cells induced by coculturing with fibroblasts.

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Implication

Randomized trial investigates how irradiated fibroblasts affect IL-6 and HNSCC migration, indicating potential intervention strategies.

Cite This Study

Suzuki et al. (2022) studied this question.

synapsesocial.com/papers/6a6ef64fe36a167817e0be0f https://doi.org/10.1371/journal.pone.0262549

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Irradiated fibroblasts increase interleukin-6 expression and induce migration of head and neck squamous cell carcinoma

Key Points

Discussion

Implication

Cite This Study

Irradiated fibroblasts increase interleukin-6 expression and induce migration of head and neck squamous cell carcinoma

Key Points

Discussion

Implication

Cite This Study

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