What does this research mean for the field?

In patients with the objective short sleep duration insomnia phenotype, elevated serum indoxyl sulfate is positively correlated with blood pressure and gut microbiota alterations, suggesting it mediates increased hypertension risk. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 31, 2025SLEEP

A multi-omics study of the association between insomnia with objective short sleep duration phenotype and high blood pressure

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Chronic insomnia disorder (n=173). Intervention: Objective short sleep duration insomnia phenotype (ISSD) vs. Normal sleepers. Primary outcome: Correlation between serum indoxyl sulfate and blood pressure (SBP: β = 0.250; DBP: β = 0.256, p=SBP: .028; DBP: .030).

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Key result

Elevated indoxyl sulfate linked to higher blood pressure in patients with short-sleep insomnia.

SBP: β = 0.250; DBP: β = 0.256
P SBP: .028; DBP: .030
n=173

Why the study?

Does the objective short sleep duration insomnia phenotype correlate with specific metabolic and microbiota changes linked to high blood pressure?

Key Points

Investigate the metabolic and gut microbiota mechanisms linking the objective short sleep duration insomnia phenotype to elevated blood pressure in patients with chronic insomnia disorder.
Evaluated 103 patients with chronic insomnia disorder and 70 normal sleepers using overnight polysomnography to classify the objective short sleep duration phenotype by median total sleep time.
Assessed nighttime and morning systolic and diastolic blood pressure alongside serum metabolomics and fecal 16S rDNA amplicon sequencing.
Identified 52 serum metabolites associated with short-sleep insomnia, among which indoxyl sulfate was positively correlated with systolic (β = 0.250, p = .028) and diastolic blood pressure (β = 0.256, p = .030) after adjustment for confounders.
Found serum indoxyl sulfate levels correlated significantly with gut microbial genera in short-sleeping insomnia patients, including Prevotella 9 (r = .378, p = .027), CAG-56 (r = -.359, p = .037), Ruminiclostridium 9 (r = -.340, p = .049), and Ruminococcus 2 (r = -.356, p = .039).

Study Design

Type

Observational (n=173)

Structured PICO

Does the objective short sleep duration insomnia phenotype correlate with specific metabolic and microbiota changes linked to high blood pressure?

Population

173 participants, comprising 103 patients with chronic insomnia disorder and 70 normal sleepers, evaluated for serum metabolomics and gut microbiota.

Exposure

Objective short sleep duration insomnia phenotype (ISSD)

Comparator

Normal sleepers

Outcome

Association between objective short sleep duration, serum metabolites, gut microbiota, and blood pressure (SBP and DBP)surrogate

Main Result

Effect estimate: SBP: β = 0.250; DBP: β = 0.256

p-value: p=SBP: .028; DBP: .030

Discussion

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Implication

The objective short sleep duration insomnia phenotype is associated with elevated serum indoxyl sulfate, which correlates with both blood pressure and specific gut microbiota, suggesting a potential molecular pathway for increased hypertension risk.

Cite This Study

Dai et al. (2025) conducted an observational in Chronic insomnia disorder (n=173). Objective short sleep duration insomnia phenotype (ISSD) vs. Normal sleepers was evaluated on Correlation between serum indoxyl sulfate and blood pressure (SBP: β = 0.250; DBP: β = 0.256, p=SBP: .028; DBP: .030). In patients with the objective short sleep duration insomnia phenotype, serum indoxyl sulfate was positively correlated with systolic (β=0.250, p=0.028) and diastolic (β=0.256, p=0.030) blood pressure.

synapsesocial.com/papers/6a6efca5ac440176ef27c388 https://doi.org/10.1093/sleep/zsaf030

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A multi-omics study of the association between insomnia with objective short sleep duration phenotype and high blood pressure

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

A multi-omics study of the association between insomnia with objective short sleep duration phenotype and high blood pressure

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

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