), the particles showed significant cytotoxicity and prolonged the M1 phenotype of macrophages. The BG particles also exhibited strong chemotaxis to macrophages which appeared to be independent of their concentration. Dose-dependent regulation of macrophages and wound closure by BG particles were also observed in the healing of full-thickness wounds of diabetic rats. Our study suggests that the BG particle-mediated activities of macrophages are essential to wound healing, and these activities are greatly correlated with the amount of BG particles.
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Xie et al. (2019) studied this question.
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