Key result
Anti-inflammatory strategies targeting metaflammation, including lifestyle changes, medications, and bariatric surgery, represent potential approaches to manage type 2 diabetes and its causes.
Why the study?
Given the role of metaflammation in driving insulin resistance and insulitis, anti-inflammatory strategies could potentially treat the underlying causes of type 2 diabetes rather than only controlling symptoms.
Do anti-inflammatory strategies improve the management of type 2 diabetes in obese individuals?
Do anti-inflammatory strategies improve the management of type 2 diabetes in obese individuals?
Targeting metaflammation with anti-inflammatory strategies represents a comprehensive approach to managing both the symptoms and underlying causes of type 2 diabetes in obesity.
Answers are grounded in this paper and cite their sources.
Metaflammation may link obesity to T2D via insulin resistance; leaves open targeted anti-inflammatory strategies pending trials.
One of the concepts explaining the coincidence of obesity and type 2 diabetes (T2D) is the metaflammation theory. This chronic, low-grade inflammatory state originating from metabolic cells in response to excess nutrients, contributes to the development of T2D by increasing insulin resistance in peripheral tissues (mainly in the liver, muscles, and adipose tissue) and by targeting pancreatic islets and in this way impairing insulin secretion. Given the role of this not related to infection inflammation in the development of both: insulin resistance and insulitis, anti-inflammatory strategies could be helpful not only to control T2D symptoms but also to treat its causes. This review presents current concepts regarding the role of metaflammation in the development of T2D in obese individuals as well as data concerning possible application of different anti-inflammatory strategies (including lifestyle interventions, the extra-glycemic potential of classical antidiabetic compounds, nonsteroidal anti-inflammatory drugs, immunomodulatory therapies, and bariatric surgery) in the management of T2D.
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Kuryłowicz et al. (2020) conducted a review in Type 2 Diabetes and Obesity. Anti-inflammatory strategies was evaluated. Anti-inflammatory strategies targeting metaflammation, including lifestyle changes, medications, and bariatric surgery, represent potential approaches to manage type 2 diabetes and its causes.
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