New tools in drug development: The catalytic enantioselective fluorination and chlorination reactions of carbonyl compounds containing an additional binding site (see scheme) proceed with extremely high enantioselectivity and require low catalyst loadings (2–10 mol % dbfox-Ph/NiII). Asymmetric amplification is also observed in these enantioselective halogenations.
No takes yet. Share an insight, caveat, or question.
Shibata et al. (2005) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: