Why the study?
Ischemic heart disease is documented with high prevalence among Asian Indian migrants, but population-specific variation in coronary artery dimensions across Southern India had not been assessed.
Are there geographic and population variations in coronary artery dimensions across Southern India?
Cross-Sectional (n=4,000)
Double-blind
Yes
Are there geographic and population variations in coronary artery dimensions across Southern India?
This multicenter cross-sectional study aims to characterize geographic and population variations in coronary artery dimensions across Southern India using quantitative coronary angiography.
Coronary dimensions vary regionally among SVD patients in Southern India; leaves open need for population-specific QCA references.
Ischemic Heart Diseases (IHD) among Asian Indian migrants in the western world are documented with high prevalence. We aimed to assess population specific variation in artery dimensions among normal and Single Vessel Disease (SVD) patients among four states of Southern India: Telangana, Karnataka, Kerala and Tamil Nadu using Quantitative Coronary Angiography (QCA) in the disease presentations. QCA of four thousand patients of Indian origin were studied prospectively after procuring the ethical clearance. Informed consents were obtained. Post Percutaneous Coronary Angioplasty (PCI) as well as Post Coronary Bypass Operations (CABG) and patient being diabetic for ≥5 years were excluded. Principal Component Analysis (PCA) was performed with samples to identify region-specific clustering.
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A et al. (2022) conducted a cross-sectional in Coronary Artery Disease (n=4,000). Geographic region (Southern Indian states) vs. Between-region comparison was evaluated on Coronary artery dimensions (LAD-o and LAD-p segments) (p=<0.0001).
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