Key result
Combined ETA- and ETB-receptor antagonism with PD145065 significantly reduced infarct size compared to control in a rabbit model of myocardial infarction (22% vs 47%; p<=0.02).
Why the study?
Does endothelin receptor antagonism reduce infarct size and arrhythmias in a rabbit model of acute myocardial infarction?
Population
Rabbit model of acute myocardial infarction (30 min circumflex occlusion followed by reperfusion)
Comparison
Exogenous ET-1, FR139317, or PD145065 vs Saline
Design
Preclinical
Follow-up
48 hours
Authors
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ET may promote post-MI arrhythmias in rabbits; leaves open clinical relevance of ETA/ETB antagonism.
Does endothelin receptor antagonism reduce infarct size and arrhythmias in a rabbit model of acute myocardial infarction?
Absolute Event Rate: 22% vs 47%
p-value: p=<=0.02
Blockade of both ETA and ETB receptors significantly reduces infarct size and ventricular arrhythmias in a rabbit model of ischemia-reperfusion, suggesting a deleterious role of endothelin.
Vítola et al. (1996) studied Acute myocardial infarction. PD145065 (ETA- and ETB-receptor antagonist) vs. Saline (control) was evaluated on Infarct size as a percentage of the area at risk (AN/AR) (p=<=0.02). Combined ETA- and ETB-receptor antagonism with PD145065 significantly reduced infarct size compared to control in a rabbit model of myocardial infarction (22% vs 47%; p<=0.02).
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