Oxidative stress and multiple sclerosis: trajectories and possible predictive activities of pro and antioxidant biomolecules

Valeria Bellisario; Giulia Squillacioti; Paola Valentino; Luca Marozio; Antonio Bertolotto; Roberto Bono

doi:10.1016/j.freeradbiomed.2025.09.052

October 4, 2025Free Radical Biology and MedicineOpen Access

Oxidative stress and multiple sclerosis: trajectories and possible predictive activities of pro and antioxidant biomolecules

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Key Points

Synthesize the pathophysiological roles of oxidative stress and antioxidant mechanisms in multiple sclerosis progression and evaluate their utility as predictive biomarkers.
Reviewed literature examining the interplay between pro-oxidant biomolecules, antioxidant defenses, and lesion pathogenesis in multiple sclerosis.
Elevated oxidative stress and reduced antioxidant capacity emerge early in multiple sclerosis, driving initial inflammatory lesion development.
Oxidative stress functions reciprocally as both an inciting trigger and an aggravating consequence of neuroinflammation, establishing a damaging self-sustaining cycle.
Pro- and antioxidant biomolecules demonstrate potential as early prognostic indicators to monitor disease progression and guide timely clinical management.

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Implication

Review highlights elevated oxidative stress and impaired antioxidant defenses in multiple sclerosis, suggesting biomolecules could serve as early prognostic markers.

Abstract

• Oxidative stress drives lesion development in multiple sclerosis. • MS patients show high OS and reduced antioxidant defense early on. • OS markers may help in early prognosis and guide timely treatment. • OS can both trigger and worsen MS, creating a harmful cycle. • More research is needed to link OS with neuroinflammation in MS.

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Bellisario et al. (2025) studied this question.

synapsesocial.com/papers/6a6f1a55c1a24a6142db4d40 https://doi.org/10.1016/j.freeradbiomed.2025.09.052

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Oxidative stress and multiple sclerosis: trajectories and possible predictive activities of pro and antioxidant biomolecules

Key Points

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Implication

Abstract

Discussion

Cite This Study

Oxidative stress and multiple sclerosis: trajectories and possible predictive activities of pro and antioxidant biomolecules

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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