Key result
APOE remains the only robust lipid-related gene linked to sporadic Alzheimer's disease risk.
Alzheimer's disease (AD)-the most common type of dementia among the elderly-represents one of the most challenging and urgent medical mysteries affecting our aging population. Although dominant inherited mutation in genes involved in the amyloid metabolism can elicit familial AD, the overwhelming majority of AD cases, dubbed sporadic AD, do not display this Mendelian inheritance pattern. Apolipoprotein E (APOE), the main lipid carrier protein in the central nervous system, is the only gene that has been robustly and consistently associated with AD risk. The purpose of the current paper is thus to highlight the pleiotropic roles and the structure-function relationship of APOE to stimulate both the functional characterization and the identification of novel lipid homeostasis-related molecular targets involved in AD.
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Leduc et al. (2011) conducted a review in Alzheimer's Disease. Apolipoprotein E (APOE) was evaluated. Apolipoprotein E (APOE) is the only gene robustly and consistently associated with sporadic Alzheimer's disease risk, highlighting its potential as a lipid homeostasis-related molecular target.
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