Tip-enhanced Raman scattering (TERS) and high-resolution bio nano-analysis—a comparison

This perspective presents and assesses the development and capabilities of tip-enhanced Raman scattering (TERS) since its discovery in 2000. So far, this technique has proven to be valuable for studies of a variety of inorganic, organic and biochemical specimens. Due to its ability to provide chemical and topographic characterization in a single experiment at a sub-100 nm resolution, TERS has gained importance in super-resolution structural analysis. In this contribution the focus is set on applications with relevance in the biology and medical fields. The potential and challenges of this near-field technique are discussed with respect to state-of-the-art microscopic and spectroscopic imaging methods. Furthermore, possible ways to surpass current boundaries and an outlook to future projects are presented.