Key result
Multimodality imaging with speckle tracking echocardiography and cardiac magnetic resonance identified subclinical left ventricular systolic dysfunction in two cases of LVNC with preserved LVEF.
Why the study?
Current LVNC definitions omit functional criteria despite LV dysfunction correlating with complications, and multimodality imaging may detect earlier subclinical systolic dysfunction.
Does multimodality imaging improve the diagnosis and characterization of subclinical dysfunction in left ventricular non-compaction?
Case Report (n=2)
Does multimodality imaging improve the diagnosis and characterization of subclinical dysfunction in left ventricular non-compaction?
Multimodality imaging using STE and CMR may improve the definition and characterization of LVNC by detecting early subclinical LV dysfunction.
Hypothesis-generating for multimodality imaging in LVNC; does not support practice change.
Left ventricular non-compaction (LVNC) is an increasingly recognized phenotype. The current definition of the LVNC does not mention LV dysfunction as an absolute criterion in addition to morphological criteria. LV dilatation and decreased LV ejection fraction (LVEF) are often late manifestations of the disease and correlate with the occurrence of cardiovascular complications. However, to define LVNC as a cardiomyopathy, functional criteria must be fulfilled, in addition to the morphological ones. Multimodality imaging, such as myocardial deformation and myocardial work analysis derived from speckle tracking echocardiography (STE), in combination with cardiac magnetic resonance (CMR) might improve diagnosis and characterization of non-compaction, exposing earlier signs of LV systolic dysfunction. We present two comparative cases of LVNC in order to highlight the idea of subclinical dysfunction even in apparently benign forms with preserved LVEF, and also the importance of multimodality imaging approach.
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Vișoiu et al. (2021) conducted a case report in Left ventricular non-compaction (LVNC) (n=2). Multimodality imaging (speckle tracking echocardiography and cardiac magnetic resonance) was evaluated on Subclinical left ventricular systolic dysfunction. Multimodality imaging with speckle tracking echocardiography and cardiac magnetic resonance identified subclinical left ventricular systolic dysfunction in two cases of LVNC with preserved LVEF.
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