Key result
Transfusion-dependent patients with β-thalassemia had a 13.3% (95% CI 8.6-20.1) prevalence of left ventricular noncompaction, which was associated with higher odds of heart failure (OR 1.77; 95% CI 0.29-10.89).
Why the study?
What is the prevalence and what are the risk factors for left ventricular noncompaction in transfusion-dependent patients with β-thalassemia?
Cross-Sectional (n=135)
What is the prevalence and what are the risk factors for left ventricular noncompaction in transfusion-dependent patients with β-thalassemia?
Patients with β-thalassemia have a relatively high prevalence (13.3%) of left ventricular noncompaction on cardiac MRI, which is not explained by conventional risk factors or iron overload.
No takes yet. Share an insight, caveat, or question.
LVNC occurs frequently in transfusion-dependent β-thalassemia independent of iron overload; leaves open its clinical significance and need for targeted screening.
Piga et al. (2012) conducted a cross-sectional in β-thalassemia (n=135). β-thalassemia was evaluated on Prevalence of left ventricular noncompaction (LVNC) (95% CI 8.6-20.1). Transfusion-dependent patients with β-thalassemia had a 13.3% (95% CI 8.6-20.1) prevalence of left ventricular noncompaction, which was associated with higher odds of heart failure (OR 1.77; 95% CI 0.29-10.89).
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: