Key result
Application of 40 microM ADP to human platelets activated a rapid transient inward current (peak 13-31 pA), whereas thrombin did not elicit detectable currents.
ADP rapidly activates a transient inward current in human platelets, which may account for the rapid calcium influx observed during agonist stimulation.
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Should not alter antiplatelet strategies; supports mechanistic studies of ADP-gated platelet currents.
Mahaut‐Smith et al. (1992) studied this question. ADP vs. Thrombin or baseline was evaluated on Transient inward current. Application of 40 microM ADP to human platelets activated a rapid transient inward current (peak 13-31 pA), whereas thrombin did not elicit detectable currents.