In theory, oxidative coupling is a straightforward method for reducing the number of synthetic steps, avoiding the preparation of pre-activated substrates and less waste co-product generation by using metal salts. However, attempts at oxidative cross-coupling are challenging due to its limited synthetic applications and chemoselective issues. In recent years new oxidative coupling methods have emerged, using the C-H bond of the two substrates, and enabling the selective formation of cross-coupling products
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Dohi et al. (2021) studied this question.
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