Key result
High Substance P levels linked to ~5.3-fold higher 30-day mortality in severe acute ischemic stroke.
Why the study?
Are higher serum concentrations of Substance P associated with increased 30-day mortality in patients with severe acute ischemic stroke?
Cohort (n=61)
Yes
Are higher serum concentrations of Substance P associated with increased 30-day mortality in patients with severe acute ischemic stroke?
Elevated serum Substance P levels (>362 pg/mL) serve as a significant predictor of 30-day mortality in patients with severe acute ischemic stroke.
Answers are grounded in this paper and cite their sources.
Elevated Substance P may flag higher short-term mortality risk in severe stroke; leaves open its added value for risk stratification.
Substance P (SP), a member of tachykinin family, is involved in the inflammation of the central nervous system and in the appearance of cerebral edema. Higher serum levels of SP have been found in 18 patients with cerebral ischemia compared with healthy controls. The aim of our multi-center study was to analyze the possible association between serum levels of SP and mortality in ischemic stroke patients. We included patients with malignant middle cerebral artery infarction (MMCAI) and a Glasgow Coma Scale (GCS) lower than 9. Non-surviving patients at 30 days (n = 31) had higher serum concentrations of SP levels at diagnosis of severe MMCAI than survivors (n = 30) (p < 0.001). We found in multiple regression an association between serum concentrations of SP higher than 362 pg/mL and mortality at 30 days (Odds Ratio = 5.33; 95% confidence interval = 1.541-18.470; p = 0.008) after controlling for age and GCS. Thus, the major novel finding of our study was the association between serum levels of SP and mortality in patients suffering from severe acute ischemic stroke.
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Lorente et al. (2016) conducted a cohort in Severe acute ischemic stroke (malignant middle cerebral artery infarction) (n=61). Serum concentrations of Substance P > 362 pg/mL vs. Serum concentrations of Substance P ≤ 362 pg/mL was evaluated on Mortality at 30 days (OR 5.33, 95% CI 1.541-18.470, p=0.008). Serum concentrations of Substance P higher than 362 pg/mL were significantly associated with an increased 30-day mortality (OR 5.33) in patients with severe acute ischemic stroke.
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